[1]文亚飞,王福财,许晓英,等.虾青素微胶囊对Hp小鼠血清及胃黏膜细胞因子的影响[J].华侨大学学报(自然科学版),2023,44(6):727-734.[doi:10.11830/ISSN.1000-5013.202306019]
　WEN Yafei,WANG Fucai,XU Xiaoying,et al.Effect of Astaxanthin Microcapsules on Serum and Gastric Mucosal Cytokines of Hp Mice[J].Journal of Huaqiao University(Natural Science),2023,44(6):727-734.[doi:10.11830/ISSN.1000-5013.202306019]
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虾青素微胶囊对Hp小鼠血清及胃黏膜细胞因子的影响()
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《华侨大学学报（自然科学版）》[ISSN:1000-5013/CN:35-1079/N]

卷:
第44卷
期数:
2023年第6期
页码:
727-734
栏目:
出版日期:
2023-11-20

文章信息/Info

Title:
Effect of Astaxanthin Microcapsules on Serum and Gastric Mucosal Cytokines of Hp Mice
文章编号:
1000-5013(2023)06-0727-08
作者:
文亚飞1;  王福财1;  许晓英1;  陈韵琪1;  吴振2;  王立强1
1. 华侨大学 生物医学学院, 福建 泉州 362021;2. 厦门大学 药学院, 福建 厦门 361102
Author(s):
WEN Yafei1;  WANG Fucai1;  XU Xiaoying1; CHEN Yunqi1;  WU Zhen2;  WANG Liqiang1
1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; 2. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
关键词:
虾青素;  幽门螺杆菌;  胃炎;  细胞因子
Keywords:
astaxanthin;  Helicobacter pylori;  gastritis;  cytokines
分类号:
R96
DOI:
10.11830/ISSN.1000-5013.202306019
文献标志码:
A
摘要:
采用幽门螺杆菌(Hp)灌胃法建立Hp感染小鼠模型,收集小鼠血清及胃组织。通过染色法观察小鼠胃黏膜内Hp定植量及病理学改变,通过酶标记测定法检测小鼠血清及胃黏膜HMGB1,IL-6,TNF-α,IL-4和IL-10的质量浓度。结果表明:与对照组相比,虾青素微胶囊(ASX-MCs)可降低小鼠胃黏膜内Hp定植量,减轻胃黏膜炎症损伤,降低血清和胃黏膜促炎因子HMGB1,IL-6,TNF-α的质量浓度,并提高抑炎因子IL-4和IL-10的质量浓度;ASX-MCs可减轻Hp感染引起的小鼠胃黏膜炎症损伤,抑制血清和胃黏膜促炎因子的表达,促进抑炎因子的表达。
Abstract:
A mouse model of Helicobacter pylori(Hp)infection using the Hp gavage method is established, and the mouse serum and gastric tissue are collected. The amount of Hp colonization and pathological changes of mouse gastric mucosa are observed through staining method, and the mass concentrations of HMGB1, IL-6, TNF-α, IL-4 and IL-10 from serum and gastric mucosa of mice are detected through enzyme labeling assay method. The results show that,compared with the control group,astaxanthin microcapsules(ASX-MCs)can reduce the amount of Hp colonization in gastric mucosa of mouse, alleviate the gastric mucosal inflammatory damage, reduce the serum and gastric mucosal pro-inflammatory factors such as HMGB1, IL-6 and TNF-α, and increase the mass concentration of anti-inflammatory factors IL-4 and IL-10. Morever, ASX-MCs can alleviate mouse gastric mucosal inflammatory damage caused by Hp infection,inhibit the expression of pro-inflammatory factors of serum and gastric mucosa, and promote the expression of anti-inflammatory factors.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2023-06-01
通信作者: 王立强(1970-),男,教授,博士,主要从事药剂学和创新药物研发的研究。 E-mail:wlq1599@163.com。
基金项目: 国家重点研发计划项目(2016YFE0101700); 福建省高校产学合作重大项目(2019Y4007)
更新日期/Last Update: 2023-11-20